I've long been a fan of North Course. I did my road race school on the Grand Course (something that doesn't get run much and covers about every paved area on the facility) but learned to enjoy the North Course. My first several track days coming up to speed were on North, and it became a favorite.
When I got to run the South Course all by itself, I started to really hate it. By that point in time I had ridden VIR Grand, North, Full; Barber, Jennings, CMP, Road Atlanta and probably a course or two that I've forgotten. And VIR South was to me the worst of them by any means. I then talked to a few NESBA Control Riders, and had the benefit of doing a track walk (if you can do one, please do. It will transform ANY track) with NESBA's own JRA. After which, I look forward to any outing at VIR South, and actually prefer it over several other tracks. While I still like VIR North more from a comfort standpoint, I now enjoy riding the South Course thanks to JRA taking the time to walk and explain things. And I look forward to returning and hopefully walking it with him again.
If you get the chance, please do ride them both. Definitely great things to have in the experience bucket list as it were.