I'm going to ask, "WHY?"
I'm asking this because I guess I want a little deeper understanding as to why you're considering this option.
It may not be too bad living in Florida. Have you considered where you're going to park it as a "Home Base". Are we looking at some sort of RV park that provides you utility service connections for water/sewer/electric?
A decent new 5th wheel RV is a VERY nice rig in the area of $50K, plus another $60Kish for your F350/3500 series tow vehicle with diesel. Both are items that will not hold any sort of value whatsoever and unlike a real house, you can only probably deduct the interest you pay on the RV.
Not saying that you'll buy new on either item, just using those numbers/thoughts as a basis for the discussion.
You pose a unique and interesting question...don't know the answer that works for you best..just offering some random "food for thought" type stuff.
I have a house, and I'm also a toy hauler (29 foot) owner after many years of towing and camping in the typical 6x14 Carmate utility box trailer. I decided I wanted a few more creature comforts after my 7th season with NESBA. I figured that many years was enough to consider myself committed to this hobby enough to justify the cost. I looked at the Fuzion's, etc...and opted for the slightly smaller Forest River XLR series travel trailer style. It's pretty nice, a little easier to store and manage on the road, sleeps 4 nicely enough, and at 24K brand new was a pretty good deal at the RV outlet right outside VIR.